Case Report: An unusual case of incomplete isosexual precocious puberty in a young girl with juvenile hypothyroidism
نویسندگان
چکیده
Long-standing untreated primary hypothyroidism is an uncommon cause of praecocious puberty. The hypothyroidism, incomplete sexual maturation, galactorrhoea, and pituitary enlargement are reversed or corrected by levothyroxine therapy within a few months. We report a young girl with juvenile hypothyroidism who presented with early onset of menarche with failure of growth who was treated successfully with levothyroxine with resolution of early onset pubertal changes.
منابع مشابه
A Rare Cause of Precocious Puberty and Massive Ovarian Cysts Associated with Hypothyroidism
Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, isosexual precocious puberty and massive ovarian cysts. We report such a case in a 7-yearold girl who presented with a bilateral pelvic pain, abdominal distension and signs of hypothyroidism. Physical examination showed a breast development and lack of pubic and axillary hair. There was no clitoromeg...
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Precocious puberty may be classified as true precocious puberty or precocious pseudopuberty. The latter one in females may be in sexual (feminization) or hereto sexual (virilization). Ovarian tumors may be iso sexual call tumor, teratoma, etc, are among the etiologic factors of precocious psudopuberty. This paper presents a 4-year girl was admitted to the hospital with severe abdominal pain. ...
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Hypothyroidism is usually associated with delayed pubertal development but in rare occasions precocious puberty may ensue which is seen in cases of prolonged and untreated hypothyroidism. This is also called the Van Wyk Grumbach syndrome. Here we present 4 cases of precocious puberty due to hypothyroidism.
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In boys precocious puberty is defined as the development of secondary sexual characters before 9 year of age. In girls, the development of breasts (thelarche) before 7.5 year, the development of pubic hairs (pubarche) before 8.5 year or menarche before the age of 9.5 year is considered precocious [1]. Hypothyroidism is usually associated with delayed puberty and rarely with precocious puberty [...
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The association in young females of long-standing primary hypothyroidism, isosexual precocious pseudopuberty and multicystic enlarged ovaries was first described in 1960 by Van Wyk and Grumbach. Since then, sporadic case reports have contributed to clarifying the key features of this syndrome. The unique elements that lead to this diagnosis are FSH-dominated sexual precocity combined with a del...
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